Open AccessPrognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma
Author(s) -
Gengyan Xiong,
Jin Liu,
Qi Tang,
Yu Fan,
Fang Dong,
Kaiwei Yang,
Feng Xie,
Min Zhang,
Lei Zhang,
Libo Liu,
Cuijian Zhang,
Lin Yao,
Li Yang,
Weimin Ci,
Wei Zhao,
Yanqing Gong,
Qun He,
Kan Gong,
Zhisong He,
Gang Wang,
Xuesong Li,
Yinglu Guo,
Liqun Zhou
Publication year - 2015
Publication title -
epigenomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.265
H-Index - 60
eISSN - 1750-1911
pISSN - 1750-192X
DOI - 10.2217/epi.15.34
Subject(s) - biology , methylation , bladder cancer , epigenetics , dna methylation , oncology , gene , carcinoma , promoter , medicine , cancer , cancer research , gene expression , genetics
Aim: We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients. Materials & methods: Using methylation-sensitive PCR, we examined ten genes promoter methylation status in 687 UTUC patients. Results: A methylated promoter of three genes to predict higher tumor stage (T3 and T4), five genes to predict higher tumor grade (G3) and one gene to predict pN+ were certified in this study. Nine factors were significantly associated with poor cancer-specific survival. Six factors were considered as predictors to develop bladder recurrence after surgery. Conclusion: Methylation occurs commonly in UTUCs, may affect carcinogenic mechanisms, and is a well predictive factor for cancer-specific survival and bladder recurrence in UTUCs.