Open AccessClinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer
Author(s) -
Chukwuemeka Ihemelandu,
Ayesha Naeem,
Erika Parasido,
Deborah L. Berry,
Krysta Chaldekas,
Brent T. Harris,
Olga Rodriguez,
Christopher Albanese
Publication year - 2019
Publication title -
colorectal cancer
Language(s) - English
Resource type - Journals
eISSN - 1758-1958
pISSN - 1758-194X
DOI - 10.2217/crc-2019-0009
Subject(s) - lgr5 , colorectal cancer , medicine , immunohistochemistry , tissue microarray , stem cell marker , cancer , cancer stem cell , oncology , pathology , clinical significance , stem cell , predictive marker , biology , genetics
Aim: To analyze the clinicopathologic and prognostic significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a cancer stem cell marker expression in a cohort of colorectal cancer patients (CRC). Patients & methods: A total of 76 formalin-fixed paraffin-embedded tissue blocks of primary or metastatic tumors from 49 CRC patients were collected for duration 2009–2015. LGR5 expression was assessed through immunohistochemical staining of a tissue microarray. Results: LGR5 was significantly over expressed in CRC tissue samples and found to be a statistically significant independent prognostic marker for an improved overall survival. Conclusion: LGR5 expression was higher in colorectal cancer than in normal tissue. LGR5 was an independent prognostic marker for better clinical outcomes and might be used as a potential therapeutic target in CRCs.