Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis

Aim: To evaluate the use of chemotherapy and radiation, and their outcomes for patients with astroblastoma. Patients & methods: This is a retrospective review of patients extracted from the National Cancer Database. We investigated overall survival (OS) using Kaplan–Meier curves. Cox proportional hazards models were used to correlate OS with risk variables and treatments. Results: OS at 5 years was 79.5%. Patients with high-grade tumors were more likely to receive chemotherapy and radiation. Patients with high-grade astroblastoma who did not receive adjuvant radiation had poor survival. Conclusion: Patients with astroblastoma should be treated with curative intent. Radiation is likely beneficial in high-grade astroblastoma. The exact role of radiation and chemotherapy following surgical resection warrant further investigation.