BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma | Zendy

Rimas V. Lukas | Zendy; Ryan Merrell | Zendy

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BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma

Author(s) -

Rimas V. Lukas,

Ryan Merrell

Publication year - 2018

Publication title -

cns oncology

Language(s) - English

Resource type - Journals

eISSN - 2045-0915

pISSN - 2045-0907

DOI - 10.2217/cns-2017-0032

Subject(s) - pleomorphic xanthoastrocytoma , vemurafenib , medicine , concomitant , regimen , oncology , cancer research , glioma , melanoma , astrocytoma , metastatic melanoma

Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of the BRAF inhibitor vemurafenib and tumor treating fields. The regimen proved tolerable and efficacious in this case.

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