Genetic findings in sport-related concussions: potential for individualized medicine? | Zendy

Jane McDevitt | Zendy; Evgeny Krynetskiy | Zendy

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Genetic findings in sport-related concussions: potential for individualized medicine?

Author(s) -

Jane McDevitt,

Evgeny Krynetskiy

Publication year - 2017

Publication title -

concussion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.205

H-Index - 3

ISSN - 2056-3299

DOI - 10.2217/cnc-2016-0020

Subject(s) - concussion , athletes , traumatic brain injury , medicine , genotyping , incidence (geometry) , prospective cohort study , gene , physical medicine and rehabilitation , psychology , psychiatry , physical therapy , injury prevention , poison control , biology , genotype , genetics , emergency medicine , physics , optics

Concussion is a traumatic transient disturbance of the brain. In sport, the initial time and severity of concussion is known giving an opportunity for subsequent analysis. Variability in susceptibility and recovery between individual athletes depends, among other parameters, on genetic factors. The genes-encoding polypeptides that determine incidence, severity and prognosis for concussion are the primary candidates for genetic analysis. Genetic polymorphisms in the genes contributing to plasticity and repair ( APOE ), synaptic connectivity ( GRIN2A ), calcium influx ( CACNA1E ), uptake and deposit of glutamate ( SLC17A7 ) are potential biomarkers of concussion incidence and recovery rate. With catalogued genetic variants, prospective genotyping of athletes at the beginning of their career will allow medical professionals to improve concussion management and return-to-play decisions.

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