Androgen expression & clinicopathological features in male breast cancer | Zendy

Lia Pamela Rebaza Vasquez | Zendy; Carlos A. Castañeda | Zendy; Miluska Castillo | Zendy; Luis A. Bernabe | Zendy; Joselyn Sanchez | Zendy; Gabriela Calderón | Zendy; Jorge Dunstan | Zendy; Miguel De la Cruz | Zendy; José M. Cotrina | Zendy; Julio E. Abugattas | Zendy; Henry Miller | Zendy; Maria R Villa-Robles | Zendy; Nathaly Poma | Zendy; Ómar Mejìa | Zendy; Henry Gómez | Zendy

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Androgen expression & clinicopathological features in male breast cancer

Author(s) -

Lia Pamela Rebaza Vasquez,

Carlos A. Castañeda,

Miluska Castillo,

Luis A. Bernabe,

Joselyn Sanchez,

Gabriela Calderón,

Jorge Dunstan,

Miguel De la Cruz,

José M. Cotrina,

Julio E. Abugattas,

Henry Miller,

Maria R Villa-Robles,

Nathaly Poma,

Ómar Mejìa,

Henry Gómez

Publication year - 2018

Publication title -

breast cancer management

Language(s) - English

Resource type - Journals

eISSN - 1758-1931

pISSN - 1758-1923

DOI - 10.2217/bmt-2017-0027

Subject(s) - medicine , estrogen receptor , androgen receptor , male breast cancer , breast cancer , oncology , stage (stratigraphy) , immunohistochemistry , androgen , gynecology , cancer , hormone , biology , prostate cancer , paleontology

Aim: To investigate prognostic features in male breast cancer (MBC). Methods: Clinicopathological information from 40 MBC patients was retrospectively reviewed. Androgen receptor (AR) and estrogen receptor (ER) were prospectively stained out in 22 cases and counted through software program analysis. Results: Median age was 65.5 years; most cases were Stage II (40%), Grade II (37.5%), ER ≥10% (72.5%) and PgR ≥10% (75%). AR >10% was found in 17 of 22 cases. Although AR expression was correlated with ER, there are some cells without coexpression. Axillary node involvement was associated with DFS (p = 0.001) and age (p = 0.002) was associated with overall survival. Conclusion: ER is expressed in most MBC cases and is correlated with AR. Axillary involvement and age were associated with survival.

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