Open AccessMolecular regulation of miRNAs and potential biomarkers in the progression of hepatic steatosis to NASH
Author(s) -
Yuping Wang,
Zhichao Liu,
Wen Zou,
Huasheng Hong,
Hong Fang,
Weida Tong
Publication year - 2015
Publication title -
biomarkers in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 44
eISSN - 1752-0371
pISSN - 1752-0363
DOI - 10.2217/bmm.15.70
Subject(s) - steatosis , microrna , nonalcoholic fatty liver disease , medicine , phenotype , fatty liver , bioinformatics , liver injury , disease , pathogenesis , function (biology) , computational biology , gene , biology , pathology , genetics
Increasing evidence suggests that microRNAs regulate diverse biological functions in the liver and play a very important function in metabolic-related disorders such as nonalcoholic fatty liver disease via regulating their target genes expression. In this review, we summarized the most recent progress in identification of miRNAs involving in the progression of liver steatosis and discussed the possible mechanisms by which miRNAs contribute to the diverse pathogenic liver injuries. We provide insights into the functional network of miRNAs by connecting miRNAs, their targets and biological pathways associated to hepatic steatosis and fibrosis, with important implications for our understanding of phenotypic-based disease pathogenesis. We also discuss the possible roles and challenges of miRNAs as biomarkers for drug-induced liver injury.