Is indirect hyperbilirubinemia a useful biomarker of reduced propofol clearance in neonates? | Zendy

Anne Smits | Zendy; Roosmarijn FW De Cock | Zendy; Veerle Cossey | Zendy; Catherijne A. J. Knibbe | Zendy; Karel Allegaert | Zendy

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Is indirect hyperbilirubinemia a useful biomarker of reduced propofol clearance in neonates?

Author(s) -

Anne Smits,

Roosmarijn FW De Cock,

Veerle Cossey,

Catherijne A. J. Knibbe,

Karel Allegaert

Publication year - 2012

Publication title -

biomarkers in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.652

H-Index - 44

eISSN - 1752-0371

pISSN - 1752-0363

DOI - 10.2217/bmm.12.25

Subject(s) - propofol , medicine , pharmacokinetics , bilirubin , biomarker , bolus (digestion) , anesthesia , biochemistry , chemistry

Large interindividual variability in neonatal propofol clearance is documented which, in part, can be explained by postmenstrual age (PMA) and postnatal age (PNA). We aimed to document whether indirect bilirubin, instead of or in addition to PNA, could improve predictability of propofol clearance and serve as a useful biomarker of reduced propofol clearance in neonates.

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