Potential biomarkers for antidiastole of tuberculous and malignant pleural effusion by proteome analysis | Zendy

Jing Shi | Zendy; Pu Li | Zendy; Lijin Zhou | Zendy; Suwen Qi | Zendy; Bo Wang | Zendy; Dandan Li | Zendy; Liang Duan | Zendy; Wei Xian Chen | Zendy; Xia Jirong | Zendy; Lin Zou | Zendy; Shuangshuang Yang | Zendy

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Potential biomarkers for antidiastole of tuberculous and malignant pleural effusion by proteome analysis

Author(s) -

Jing Shi,

Pu Li,

Lijin Zhou,

Suwen Qi,

Bo Wang,

Dandan Li,

Liang Duan,

Wei Xian Chen,

Xia Jirong,

Lin Zou,

Shuangshuang Yang

Publication year - 2019

Publication title -

biomarkers in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.652

H-Index - 44

eISSN - 1752-0371

pISSN - 1752-0363

DOI - 10.2217/bmm-2018-0200

Subject(s) - medicine , proteome , pleural effusion , differential diagnosis , pathology , biochemistry , biology

Aim: To investigate novel potential biomarkers for antidiastole of tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE). Materials & methods: iTRAQTM-coupled LC–MS/MS were applied to analyze the proteome of TPE and MPE samples. The candidate proteins were verified by enzyme-linked immunosorbent assay. Results: A total of 432 differential proteins were identified. Enzyme-linked immunosorbent assay revealed significantly higher levels of fibronectin (FN) and cathepsin G (CTSG) in MPE than in TPE, but lower levels of leukotriene-A4 hydrolase (LTA4H). The receiver operator characteristic values were 0.285 for FN, 0.64 for LTA4H, 0.337 for CTSG and 0.793 for a combination of these candidate markers. Conclusion: FN, LTA4H and CTSG were identified as potential biomarkers to differentiate TPE from MPE and their combination exhibited higher diagnostic capacity.

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