Potential Usefulness of Apolipoprotein A2 Isoforms for Screening and Risk Stratification of Pancreatic Cancer | Zendy

Kazufumi Honda | Zendy; Sudhir Srivastava | Zendy

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Potential Usefulness of Apolipoprotein A2 Isoforms for Screening and Risk Stratification of Pancreatic Cancer

Author(s) -

Kazufumi Honda,

Sudhir Srivastava

Publication year - 2016

Publication title -

biomarkers in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.652

H-Index - 44

eISSN - 1752-0371

pISSN - 1752-0363

DOI - 10.2217/bmm-2016-0209

Subject(s) - pancreatic cancer , medicine , biomarker , cancer , population , oncology , pancreas , stage (stratigraphy) , biology , biochemistry , environmental health , paleontology

Given the low incidence of pancreatic cancer in the general population, screening of pancreatic cancer in the general population using invasive modalities is not feasible. Combination of invasive screening with noninvasive biomarkers for pancreatic cancer and its precancerous lesions has the potential to reduce mortality due to pancreatic cancer. In this review, we focus on biomarkers found in the blood that can indicate early-stage pancreatic cancer, and we discuss current strategies for screening for pancreatic cancer. We recently identified a unique alteration in apolipoprotein A2 isoforms in pancreatic cancer and its precancerous lesions, and we describe its clinical usefulness as a potential biomarker for the early detection and risk stratification of pancreatic cancer.

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