Miconazole Revisited: New Evidence of Antifungal Efficacy from Laboratory and Clinical Trials | Zendy

Andrei Barasch | Zendy; Andreea Voinea Griffin | Zendy

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Miconazole Revisited: New Evidence of Antifungal Efficacy from Laboratory and Clinical Trials

Author(s) -

Andrei Barasch,

Andreea Voinea Griffin

Publication year - 2008

Publication title -

future microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.797

H-Index - 82

eISSN - 1746-0921

pISSN - 1746-0913

DOI - 10.2217/17460913.3.3.265

Subject(s) - miconazole , antifungal , azole , ergosterol , clinical trial , pharmacology , mode of action , medicine , clinical efficacy , fungicide , biology , dermatology , toxicology , biochemistry , botany

In the past 40 years imidazoles have been used extensively in medicine for their antifungal properties. All members of the azole antifungal family inhibit ergosterol biosynthesis. However, the discovery of an additional fungicidal mode of action for miconazole has drawn renewed attention to this compound. In this article we review recent evidence of mechanistic efficacy, as well as clinical trial results of miconazole in new topical formulations.

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