Open AccessRole of Gemcitabine in the Treatment of Ovarian Cancer
Author(s) -
Fadi Abushahin,
Peter G. Rose
Publication year - 2007
Publication title -
women s health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.363
H-Index - 39
eISSN - 1745-5065
pISSN - 1745-5057
DOI - 10.2217/17455057.3.3.279
Subject(s) - gemcitabine , carboplatin , ovarian cancer , oncology , medicine , pharmacokinetics , pharmacology , platinum , cancer , chemotherapy , cisplatin , chemistry , biochemistry , catalysis
The US FDA has recently approved the combination of carboplatin and gemcitabine as a second-line therapy for recurrent platinum-sensitive ovarian cancer. This article briefly reviews the pharmacokinetics and mechanism of action of gemcitabine and its synergistic effect with platinum. An overview of the literature on the role of gemcitabine in the treatment of epithelial ovarian cancer is also presented.
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