Open AccessLeflunomide Efficacy and Pharmacodynamics for the Treatment of BK Viral Infection
Author(s) -
Jill C. Krisl,
David J. Taber,
Nicole A. Pilch,
Kenneth D. Chavin,
Charles F. Bratton,
Beje Thomas,
John W. McGillicuddy,
Prabhakar K. Baliga
Publication year - 2012
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.12531211
Subject(s) - leflunomide , bk virus , medicine , viral load , pharmacodynamics , viremia , discontinuation , pharmacology , immunology , kidney transplantation , transplantation , pharmacokinetics , virus , methotrexate
BK virus is an infection in kidney transplantation patients jeopardizing graft survival. Unfortunately, there is no consensus on treatment of BK viremia and nephropathy. Leflunomide has been studied for the treatment of BK viremia and nephropathy, but there are limited data on the utility of leflunomide therapeutic drug monitoring. This study aimed to determine if a pharmacodynamic relationship exists between BK viral load reduction and leflunomide metabolite, A77 1726, serum concentrations.
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