Management of Membranous Nephropathy in the PLA2R Era
Author(s) -
Andrew S. Bomback
Publication year - 2017
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.12461117
Subject(s) - medicine , membranous nephropathy , glomerulonephritis , kidney
Membranous nephropathy (MN) occurs when circulating antibodies permeate the glomerular basement membrane and in the subepithelial space, form immune complexes with epitopes on podocyte membranes. One dominant antigen on podocytes is the M-type phospholipase A2 receptor (PLA2R), accounting for
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