A Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function | Zendy

Mehmet Kanbay | Zendy; Bülent Huddam | Zendy; Alper Azak | Zendy; Yalçın Solak | Zendy; Gulay Kocak Kadioglu | Zendy; İsmail Kırbaş | Zendy; Murat Duranay | Zendy; Adrian Covic | Zendy; Richard J. Johnson | Zendy

Open Access

A Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function

Author(s) -

Mehmet Kanbay,

Bülent Huddam,

Alper Azak,

Yalçın Solak,

Gulay Kocak Kadioglu,

İsmail Kırbaş,

Murat Duranay,

Adrian Covic,

Richard J. Johnson

Publication year - 2011

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.11451210

Subject(s) - medicine , hyperuricemia , allopurinol , asymptomatic , gout , uric acid , renal function , endothelial dysfunction , febuxostat , c reactive protein , gastroenterology , proteinuria , endocrinology , kidney , inflammation

Endothelial dysfunction is an early manifestation of vascular injury and contributes to the development of atherosclerotic cardiovascular disease. Recent studies have implicated hyperuricemia as a risk factor for cardiovascular disease. We hypothesized that lowering uric acid in subjects with asymptomatic hyperuricemia with allopurinol might improve endothelial dysfunction, BP, estimated GFR (eGFR), and inflammatory markers.

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