Open AccessIntradialytic Hypertension and its Association with Endothelial Cell Dysfunction
Author(s) -
Jula K. Inrig,
Peter Van Buren,
Catherine Kim,
Wanpen Vongpatanasin,
Thomas J. Povsic,
Robert D. Toto
Publication year - 2011
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.11351210
Subject(s) - medicine , endothelial dysfunction , brachial artery , cardiology , endothelium , blood pressure , hemodialysis , progenitor cell , endothelial stem cell , endothelial progenitor cell , stem cell , biochemistry , chemistry , biology , in vitro , genetics
Intradialytic hypertension is associated with adverse outcomes, yet the mechanism is uncertain. Patients with intradialytic hypertension exhibit imbalances in endothelial-derived vasoregulators nitric oxide and endothelin-1, indirectly suggesting endothelial cell dysfunction. We hypothesized that intradialytic hypertension is associated in vivo with endothelial cell dysfunction, a novel predictor of adverse cardiovascular outcomes.