Expression of Fibroblast Growth Factor 23, Vitamin D Receptor, and Sclerostin in Bone Tissue from Hypercalciuric Stone Formers | Zendy

Viviane Barcellos Me | Zendy; Rosa Maria Affonso Moysés | Zendy; Samirah Abreu Gomes | Zendy; Aluízio Barbosa Carvalho | Zendy; Vanda Jorgetti | Zendy; Ita Pfeferman Heilberg | Zendy

Open Access

Expression of Fibroblast Growth Factor 23, Vitamin D Receptor, and Sclerostin in Bone Tissue from Hypercalciuric Stone Formers

Author(s) -

Viviane Barcellos Me,

Rosa Maria Affonso Moysés,

Samirah Abreu Gomes,

Aluízio Barbosa Carvalho,

Vanda Jorgetti,

Ita Pfeferman Heilberg

Publication year - 2014

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.10030913

Subject(s) - sclerostin , immunostaining , medicine , calcitriol receptor , endocrinology , bone resorption , resorption , vitamin d and neurology , fibroblast growth factor 23 , osteoid , immunohistochemistry , parathyroid hormone , chemistry , calcium , biochemistry , wnt signaling pathway , gene

Increased bone resorption, low bone formation, and abnormal mineralization have been described in stone formers with idiopathic hypercalciuria. It has been previously shown that the receptor activator of NF-κB ligand mediates bone resorption in idiopathic hypercalciuria (IH). The present study aimed to determine the expression of fibroblast growth factor 23 (FGF-23), vitamin D receptor (VDR), and sclerostin in bone tissue from IH stone formers.

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