Simulation-Based Sodium Thiosulfate Dosing Strategies for the Treatment of Calciphylaxis | Zendy

Rajendra Singh | Zendy; Hartmut Derendorf | Zendy; Edward A. Ross | Zendy

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Simulation-Based Sodium Thiosulfate Dosing Strategies for the Treatment of Calciphylaxis

Author(s) -

Rajendra Singh,

Hartmut Derendorf,

Edward A. Ross

Publication year - 2011

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.09671010

Subject(s) - calciphylaxis , dosing , medicine , hemodialysis , sodium thiosulfate , dialysis , pharmacokinetics , renal function , urology , nomogram , medical prescription , pharmacology , inorganic chemistry , chemistry , calcification

Calciphylaxis remains a poorly understood life-threatening disorder with limited therapeutic options. Sodium thiosulfate (STS) has reported efficacy, thought to be because solubilizing calcium deposits promote clearance by hemodialysis (HD). Lack of rigorous pharmacokinetic studies makes it problematic for determining proper STS dosing given the expanding range of dialysis prescriptions and intensities.

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