Monitoring of CD4+CD25highIL-7Rαhigh activated T Cells in Kidney Transplant Recipients | Zendy

Laure Vallotton | Zendy; Karine Hadaya | Zendy; Jean-Pierre Venetz | Zendy; Leo Buehler | Zendy; Donatella Ciuffreda | Zendy; Ghaleb Nseir | Zendy; Laura Codarri | Zendy; Jean Villard | Zendy; Giuseppe Pantaleo | Zendy; Manuel Pascual | Zendy

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Monitoring of CD4+CD25highIL-7Rαhigh activated T Cells in Kidney Transplant Recipients

Author(s) -

Laure Vallotton,

Karine Hadaya,

Jean-Pierre Venetz,

Leo Buehler,

Donatella Ciuffreda,

Ghaleb Nseir,

Laura Codarri,

Jean Villard,

Giuseppe Pantaleo,

Manuel Pascual

Publication year - 2011

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.09611010

Subject(s) - tact , medicine , immunosuppression , kidney transplantation , transplantation , foxp3 , il 2 receptor , immunology , immune system , t cell , psychology , psychotherapist

In humans, circulating CD4(+)CD25(high) T cells contain mainly regulatory T cells (Treg; FoxP3(+)IL-7Rα(low)), but a small subset is represented by activated effector T cells (Tact; FoxP3(-)IL-7Rα(high)). The balance between Tact and Treg may be important after transplantation. The aim of this study was first to analyze and correlate CD4(+)CD25(high) Tact and Treg with the clinical status of kidney transplant recipients and second to study prospectively the effect of two immunosuppressive regimens on Tact/Treg during the first year after transplantation.

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