Short-Term Effects of Rituximab in Children with Steroid- and Calcineurin-Dependent Nephrotic Syndrome | Zendy

Pietro Ravani | Zendy; Alberto Magnasco | Zendy; Alberto Edefonti | Zendy; Luisa Murer | Zendy; Rossella Rossi | Zendy; Luciana Ghio | Zendy; Elisa Benetti | Zendy; Floriana Scozzola | Zendy; Andrea Pasini | Zendy; Nadia Dallera | Zendy; Felice Sica | Zendy; Mirco Belingheri | Zendy; Francesco Scolari | Zendy; Gian Marco Ghiggeri | Zendy

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Short-Term Effects of Rituximab in Children with Steroid- and Calcineurin-Dependent Nephrotic Syndrome

Author(s) -

Pietro Ravani,

Alberto Magnasco,

Alberto Edefonti,

Luisa Murer,

Rossella Rossi,

Luciana Ghio,

Elisa Benetti,

Floriana Scozzola,

Andrea Pasini,

Nadia Dallera,

Felice Sica,

Mirco Belingheri,

Francesco Scolari,

Gian Marco Ghiggeri

Publication year - 2011

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.09421010

Subject(s) - medicine , calcineurin , rituximab , prednisone , nephrotic syndrome , proteinuria , randomized controlled trial , gastroenterology , urology , transplantation , kidney , lymphoma

Prednisone and calcineurin inhibitors are the mainstay therapy of idiopathic nephrotic syndrome (INS) in children. However, drug dependence and toxicity associated with protracted use are common. Case series suggest that the anti-CD20 monoclonal antibody rituximab (RTX) may maintain disease remission.

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