The Glomerulus | Zendy

Martin R. Pollak | Zendy; Susan E. Quaggin | Zendy; Melanie P. Hoenig | Zendy; Lance D. Dworkin | Zendy

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The Glomerulus

Author(s) -

Martin R. Pollak,

Susan E. Quaggin,

Melanie P. Hoenig,

Lance D. Dworkin

Publication year - 2014

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.09400913

Subject(s) - glomerulus , glomerular basement membrane , kidney glomerulus , nephron , basement membrane , medicine , renal glomerulus , kidney , renal function , podocyte , microbiology and biotechnology , pathology , anatomy , glomerulonephritis , biology , proteinuria

The glomerulus, the filtering unit of the kidney, is a unique bundle of capillaries lined by delicate fenestrated endothelia, a complex mesh of proteins that serve as the glomerular basement membrane and specialized visceral epithelial cells that form the slit diaphragms between interdigitating foot processes. Taken together, this arrangement allows continuous filtration of the plasma volume. The dynamic physical forces that determine the single nephron glomerular filtration are considered. In addition, new insights into the cellular and molecular components of the glomerular tuft and their contribution to glomerular disorders are explored.

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