Influence of Urine Creatinine on the Relationship between the Albumin-to-Creatinine Ratio and Cardiovascular Events | Zendy

Caitlin E. Carter | Zendy; Ronald T. Gansevoort | Zendy; Lieneke Scheven | Zendy; Hiddo J.L. Heerspink | Zendy; Michael G. Shlipak | Zendy; Paul E. de Jong | Zendy; Joachim H. Ix | Zendy

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Influence of Urine Creatinine on the Relationship between the Albumin-to-Creatinine Ratio and Cardiovascular Events

Author(s) -

Caitlin E. Carter,

Ronald T. Gansevoort,

Lieneke Scheven,

Hiddo J.L. Heerspink,

Michael G. Shlipak,

Paul E. de Jong,

Joachim H. Ix

Publication year - 2012

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.09300911

Subject(s) - creatinine , medicine , urine , albumin , renal function , urology

In the albumin-to-creatinine ratio (spot-ACR), urine creatinine corrects for tonicity but also reflects muscle mass. Low muscle mass is associated with cardiovascular disease (CVD). We hypothesized that the spot-ACR would be higher in women, lower-weight persons, and older individuals, independent of timed urine albumin excretion (24hr-UAE), and accordingly, that spot-ACR would be more strongly associated with CVD events than 24hr-UAE in these subgroups.

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