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Modified C-Reactive Protein Might be a Target Autoantigen of TINU Syndrome
Author(s) -
Ying Tan,
Feng Yu,
Zhen Qu,
Tao Su,
Guangqun Xing,
Lihua Wu,
Fengmei Wang,
Gang Liu,
Yang Liu,
MingHui Zhao
Publication year - 2010
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.09051209
Subject(s) - medicine , autoantibody , pathology , kidney disease , nephropathy , antibody , immunology , diabetes mellitus , endocrinology
The cross-reactive antigen(s) of tubulointerstitial nephritis and uveitis (TINU) syndrome from renal tubulointerstitia and ocular tissue remain unidentified. The authors' recent study demonstrated that the presence of serum IgG autoantibodies against modified C-reactive protein (mCRP) was closely associated with the intensity of tubulointerstitial lesions in lupus nephritis. The study presented here investigates the possible role of IgG autoantibodies against mCRP in patients with TINU syndrome.

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