Long-Term Results of a Randomized Controlled Trial in Childhood IgA Nephropathy | Zendy

Koichi Kamei | Zendy; Koichi Nakanishi | Zendy; Shuichi Ito | Zendy; Mari Saito | Zendy; Mayumi Sako | Zendy; Kenji Ishikura | Zendy; Hiroshi Hataya | Zendy; Masataka Honda | Zendy; Kazumoto Iijima | Zendy; Norishige Yoshikawa | Zendy

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Long-Term Results of a Randomized Controlled Trial in Childhood IgA Nephropathy

Author(s) -

Koichi Kamei,

Koichi Nakanishi,

Shuichi Ito,

Mari Saito,

Mayumi Sako,

Kenji Ishikura,

Hiroshi Hataya,

Masataka Honda,

Kazumoto Iijima,

Norishige Yoshikawa

Publication year - 2011

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.08630910

Subject(s) - medicine , randomized controlled trial , combination therapy , gastroenterology , nephropathy , warfarin , azathioprine , surgery , disease , endocrinology , diabetes mellitus , atrial fibrillation

Children with IgA nephropathy showing diffuse (>80%) mesangial proliferation are at high risk for end-stage renal failure (ESRF). A previous controlled trial showed that combination therapy consisting of prednisolone, azathioprine, heparin-warfarin, and dipyridamole early in the course of disease reduces immunologic renal injury and prevents the progression of sclerosed glomeruli. The objective of this study was to evaluate the long-term effectiveness of combination therapy in children with IgA nephropathy showing diffuse mesangial proliferation.

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