Open AccessEffects of Oral Sodium Bicarbonate in Patients with CKD
Author(s) -
Matthew K. Abramowitz,
Michal L. Melamed,
Carolyn Bauer,
Amanda C. Raff,
Thomas H. Hostetter
Publication year - 2013
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.08340812
Subject(s) - medicine , sodium bicarbonate , bicarbonate , sodium , organic chemistry , chemistry
Metabolic acidosis contributes to muscle breakdown in patients with CKD, but whether its treatment improves functional outcomes is unknown. The choice of dose and tolerability of high doses remain unclear. In CKD patients with mild acidosis, this study evaluated the dose-response relationship of alkali with serum bicarbonate, its side effect profile, and its effect on muscle strength.
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