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p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease
Author(s) -
Björn Meijers,
Kathleen Claes,
Bert Bammens,
Henriëtte de Loor,
Liesbeth Viaene,
Kristin Verbeke,
Dirk Kuypers,
Yves Vanrenterghem,
Pieter Evenepoel
Publication year - 2010
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.07971109
Subject(s) - medicine , renal function , kidney disease , hazard ratio , risk factor , univariate analysis , disease , dialysis , cardiology , endocrinology , multivariate analysis , confidence interval
Cardiovascular disease is highly prevalent in chronic kidney disease. Traditional risk factors are insufficient to explain the high cardiovascular disease prevalence. Free p-cresol serum concentrations, mainly circulating as its derivative p-cresyl sulfate, are associated with cardiovascular disease in hemodialysis patients. It is not known if p-cresol is associated with cardiovascular disease in patients with chronic kidney disease not yet on dialysis.

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