Acquired Cytoresistance in the Setting of Hematopoietic Cell Transplantation

Pre-existent renal insufficiency is a widely accepted risk factor for superimposed renal damage (e.g., due to ischemia or nephrotoxic drug administration). However, both experimental renal injury and surgical ablation of renal mass in rodents confer protection against superimposed renal insults (the so-called "acquired cytoresistance" state). This study addressed whether baseline renal function is associated with either increased or decreased susceptibility to renal injury in patients undergoing hematopoietic cell transplantation (HCT), a procedure that is widely recognized to induce acute or subacute renal damage.