Prognostic Value of Glomerular Collagen IV Immunofluorescence Studies in Male Patients with X-Linked Alport Syndrome | Zendy

Laura Massella | Zendy; Concetta Gangemi | Zendy; K. Giannakakis | Zendy; Antonella Crisafi | Zendy; Tullio Faraggiana | Zendy; Chiara Fallerini | Zendy; Alessandra Renieri | Zendy; Andrea Onetti Muda | Zendy; Francesco Emma | Zendy

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Prognostic Value of Glomerular Collagen IV Immunofluorescence Studies in Male Patients with X-Linked Alport Syndrome

Author(s) -

Laura Massella,

Concetta Gangemi,

K. Giannakakis,

Antonella Crisafi,

Tullio Faraggiana,

Chiara Fallerini,

Alessandra Renieri,

Andrea Onetti Muda,

Francesco Emma

Publication year - 2013

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.07510712

Subject(s) - medicine , alport syndrome , immunofluorescence , proteinuria , glomerular basement membrane , type iv collagen , pathology , basement membrane , staining , renal biopsy , glomerulonephritis , biopsy , gastroenterology , kidney , antibody , immunology , extracellular matrix , biology , laminin , genetics

X-linked Alport syndrome (X-AS) is caused by mutations of the COL4A5 gene, which encodes for the collagen IV α5 chain (α5[COLIV]), resulting in structural and functional abnormalities of the glomerular basement membrane (GBM) and leading to CKD. The aim of the present study was to evaluate the prognostic value of residual collagen IV chain expression in the GBM of patients with X-AS.

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