The Circulating Inactive Form of Matrix Gla Protein Is a Surrogate Marker for Vascular Calcification in Chronic Kidney Disease | Zendy

Leon J. Schurgers | Zendy; Daniela Veit Barreto | Zendy; Fellype Carvalho Barreto | Zendy; Sophie Liabeuf | Zendy; C. Renard | Zendy; Elke Magdeleyns | Zendy; Cees Vermeer | Zendy; Gabriel Choukroun | Zendy; Ziad A. Massy | Zendy

Open Access

The Circulating Inactive Form of Matrix Gla Protein Is a Surrogate Marker for Vascular Calcification in Chronic Kidney Disease

Author(s) -

Leon J. Schurgers,

Daniela Veit Barreto,

Fellype Carvalho Barreto,

Sophie Liabeuf,

C. Renard,

Elke Magdeleyns,

Cees Vermeer,

Gabriel Choukroun,

Ziad A. Massy

Publication year - 2010

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.07081009

Subject(s) - matrix gla protein , medicine , calcification , kidney disease , calcinosis , renal function , cardiology , ectopic calcification

Vitamin K-dependent matrix Gla protein (MGP) acts as a calcification inhibitor in vitro and in vivo. The present study was performed to (1) determine plasma levels of the inactive, dephosphorylated, uncarboxylated MGP (dp-ucMGP) in a cohort of patients at different stages of chronic kidney disease (CKD) and (2) evaluate the association between dp-ucMGP levels on one hand and aortic calcification and mortality on the other.

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