Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease | Zendy

Kristen L. Nowak | Zendy; Wei Wang | Zendy; Heather FarmerBailey | Zendy; Berenice Y. Gitomer | Zendy; Mikaela Malaczewski | Zendy; Jelena Klawitter | Zendy; Anna Jovanovich | Zendy; Michel Chonchol | Zendy

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Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease

Author(s) -

Kristen L. Nowak,

Wei Wang,

Heather FarmerBailey,

Berenice Y. Gitomer,

Mikaela Malaczewski,

Jelena Klawitter,

Anna Jovanovich,

Michel Chonchol

Publication year - 2018

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.05850518

Subject(s) - medicine , autosomal dominant polycystic kidney disease , polycystic kidney disease , endothelial dysfunction , brachial artery , pulse wave velocity , kidney disease , arterial stiffness , endocrinology , oxidative stress , renal function , kidney , cardiology , vascular disease , pkd1 , pathology , blood pressure

Both increased arterial stiffness and vascular endothelial dysfunction are evident in patients with autosomal dominant polycystic kidney disease, even early in the course of the disease when kidney function in preserved. Vascular dysfunction in autosomal dominant polycystic kidney disease is thought to be related to vascular oxidative stress and inflammation, but direct evidence is lacking.

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