Long-Term Outcome of Biopsy-Proven, Frequently Relapsing Minimal-Change Nephrotic Syndrome in Children | Zendy

Henriette A.C. Kyrieleis | Zendy; Marije M. Löwik | Zendy; Ilse Pronk | Zendy; Hans R.M. Cruysberg | Zendy; Jan A.M. Kremer | Zendy; Wim J.G. Oyen | Zendy; Bert L. P. van den Heuvel | Zendy; Jack F.M. Wetzels | Zendy; Elena Levtchenko | Zendy

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Long-Term Outcome of Biopsy-Proven, Frequently Relapsing Minimal-Change Nephrotic Syndrome in Children

Author(s) -

Henriette A.C. Kyrieleis,

Marije M. Löwik,

Ilse Pronk,

Hans R.M. Cruysberg,

Jan A.M. Kremer,

Wim J.G. Oyen,

Bert L. P. van den Heuvel,

Jack F.M. Wetzels,

Elena Levtchenko

Publication year - 2009

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.05691108

Subject(s) - medicine , nephrotic syndrome , osteoporosis , physical examination , semen analysis , prospective cohort study , pediatrics , biopsy , infertility , pregnancy , biology , genetics

Frequently relapsing and steroid-dependent minimal-change nephrotic syndrome (MCNS) that originates in childhood can persist after puberty in >20% of patients. These patients require immunosuppressive treatment during several decades of their life. We examined long-term adverse effects of persistent nephrotic syndrome and immunosuppressive medications, focusing on renal function, growth, obesity, osteoporosis, hypertension, ocular complications, and fertility in adult patients with biopsy-proven childhood-onset MCNS. Molecular analysis was performed to evaluate a possible association of a complicated course of MCNS with podocyte gene mutations.

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