Open AccessAutoantibodies against Linear Epitopes of Myeloperoxidase in Anti–Glomerular Basement Membrane Disease
Author(s) -
Jiannan Li,
Zhao Cui,
Jia Wang,
Shuiyi Hu,
Xiaoyu Jia,
Zhe Guan,
Min Chen,
Can Xie,
MingHui Zhao
Publication year - 2016
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.05270515
Subject(s) - medicine , autoantibody , glomerular basement membrane , epitope , myeloperoxidase , disease , basement membrane , immunology , glomerulonephritis , pathology , antibody , kidney , inflammation
Approximately 20%-30% of patients with anti-glomerular basement membrane disease present coexisting anti-myeloperoxidase (MPO) autoantibodies. We previously showed the recognition of a linear fragment of the MPO heavy chain N-terminus ((1)H, MPO279-409) in plasma from most double-positive patients. Herein, we investigated the frequency of autoantibodies against overlapping (1)H-derived linear peptides in plasma from patients with anti-glomerular basement membrane disease.
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