Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression | Zendy

Teresa K. Chen | Zendy; Michael Choi | Zendy; W.H. Linda Kao | Zendy; Brad C. Astor | Zendy; Julia J. Scialla | Zendy; Lawrence J. Appel | Zendy; Liang Li | Zendy; Michael S. Lipkowitz | Zendy; Myles Wolf | Zendy; Rulan S. Parekh | Zendy; Cheryl A. Winkler | Zendy; Michelle M. Estrella | Zendy; Deidra C. Crews | Zendy

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Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression

Author(s) -

Teresa K. Chen,

Michael Choi,

W.H. Linda Kao,

Brad C. Astor,

Julia J. Scialla,

Lawrence J. Appel,

Liang Li,

Michael S. Lipkowitz,

Myles Wolf,

Rulan S. Parekh,

Cheryl A. Winkler,

Michelle M. Estrella,

Deidra C. Crews

Publication year - 2015

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.05220515

Subject(s) - medicine , hazard ratio , confidence interval , creatinine , renal function , proportional hazards model , body mass index , genotype , kidney disease , allele , blood urea nitrogen , gastroenterology , endocrinology , genetics , biology , gene

Common apolipoprotein L1 (APOL1) variants are associated with increased risk of progressive CKD; however, not all individuals with high-risk APOL1 variants experience CKD progression. Identification of factors contributing to heterogeneity has important scientific and clinical implications.

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