Staphylococcus Infection–Associated GN – Spectrum of IgA Staining and Prevalence of ANCA in a Single-Center Cohort | Zendy

Anjali A. Satoskar | Zendy; Sarah Suleiman | Zendy; Isabelle Ayoub | Zendy; Jessica Hemminger | Zendy; Samir M. Parikh | Zendy; Sergey V. Brodsky | Zendy; Cherri Bott | Zendy; Edward Calomeni | Zendy; Gyongyi Nadasdy | Zendy; Brad H. Rovin | Zendy; Lee A. Hebert | Zendy; Tibor Nádasdy | Zendy

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Staphylococcus Infection–Associated GN – Spectrum of IgA Staining and Prevalence of ANCA in a Single-Center Cohort

Author(s) -

Anjali A. Satoskar,

Sarah Suleiman,

Isabelle Ayoub,

Jessica Hemminger,

Samir M. Parikh,

Sergey V. Brodsky,

Cherri Bott,

Edward Calomeni,

Gyongyi Nadasdy,

Brad H. Rovin,

Lee A. Hebert,

Tibor Nádasdy

Publication year - 2016

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.05070516

Subject(s) - medicine , nephropathy , serology , staining , pathology , biopsy , single center , glomerulonephritis , renal biopsy , immunoglobulin a , antibody , immunology , immunoglobulin g , kidney , diabetes mellitus , endocrinology

Staphylococcus infection-associated GN (SAGN) is a well recognized disease entity, particularly because of the frequent IgA-dominant glomerular immunoglobulin staining on kidney biopsy. Biopsy features can resemble two other disease entities - primary IgA nephropathy and Henoch-Schönlein purpura nephritis - posing a diagnostic pitfall. This is clinically relevant because of the crucial difference in the therapeutic approach. The diagnosis of SAGN is further complicated by the variability in the degree of glomerular IgA (and C3) staining, the extent of electron dense immune-type deposits, and positive ANCA serology in some patients.

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