Association of Increasing GFR with Change in Albuminuria in the General Population | Zendy

Toralf Melsom | Zendy; Vidar T.N. Stefansson | Zendy; Jørgen Schei | Zendy; Marit D. Solbu | Zendy; Trond Jenssen | Zendy; Tom Wilsgaard | Zendy; Bjørn O. Eriksen | Zendy

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Association of Increasing GFR with Change in Albuminuria in the General Population

Author(s) -

Toralf Melsom,

Vidar T.N. Stefansson,

Jørgen Schei,

Marit D. Solbu,

Trond Jenssen,

Tom Wilsgaard,

Bjørn O. Eriksen

Publication year - 2016

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.04940516

Subject(s) - albuminuria , medicine , renal function , creatinine , urology , population , kidney disease , nephron , endocrinology , proteinuria , kidney , environmental health

Hyperfiltration at the single-nephron level has been proposed as an early stage of kidney dysfunction of different origins. Evidence supporting this hypothesis in humans is lacking, because there is no method of measuring single-nephron GFR in humans. However, increased whole-kidney GFR in the same individual implies an increased single-nephron GFR, because the number of nephrons does not increase with age. We hypothesized that an increase in GFR would be associated with an increased albumin-to-creatinine ratio in a cohort of the general population.

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