Immunogenicity of Augmented Compared With Standard Dose Hepatitis B Vaccine in Pediatric Patients on Dialysis: a Midwest Pediatric Nephrology Consortium Study
Author(s) -
Jason Misurac,
René G. VanDeVoorde,
Mahmoud Kallash,
Franca M. Iorember,
Kera E. Luckritz,
Michelle N. Rheault,
Jennifer G. Jetton,
Martin A. Turman,
Gaurav Kapur,
Katherine Twombley,
Shireen Hashmat,
Donald J. Weaver,
Jeffrey Leiser,
Coriilescu
Publication year - 2017
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.04750416
Subject(s) - medicine , immunogenicity , nephrology , dialysis , intensive care medicine , virology , pediatrics , immunology , antibody
Patients on maintenance dialysis have a higher risk of unresponsiveness to hepatitis B vaccination and loss of hepatitis B immunity. Adult guidelines recommend augmented dosing (40 mcg/dose), resulting in improved response in adults. We sought to determine whether children on dialysis mount a similar antibody response when given standard or augmented dosing of hepatitis B vaccine.
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