Endothelial Dysfunction in Patients with Chronic Kidney Disease Results from Advanced Glycation End Products (AGE)-Mediated Inhibition of Endothelial Nitric Oxide Synthase through RAGE Activation | Zendy

Ellena A. Linden | Zendy; Weijing Cai | Zendy; John Cijiang He | Zendy; Xue Chen | Zendy; Li Zhu | Zendy; Jonathan Winston | Zendy; Helen Vlassara | Zendy; Jaime Uribarri | Zendy

Open Access

Endothelial Dysfunction in Patients with Chronic Kidney Disease Results from Advanced Glycation End Products (AGE)-Mediated Inhibition of Endothelial Nitric Oxide Synthase through RAGE Activation

Author(s) -

Ellena A. Linden,

Weijing Cai,

John Cijiang He,

Xue Chen,

Li Zhu,

Jonathan Winston,

Helen Vlassara,

Jaime Uribarri

Publication year - 2008

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.04291007

Subject(s) - glycation , advanced glycation end product , endothelial dysfunction , medicine , reactive hyperemia , kidney disease , endocrinology , nitric oxide synthase , endothelium , diabetes mellitus , nitric oxide , vasodilation

Advanced glycation end products, known pro-inflammatory and pro-oxidative compounds that accumulate in patients with chronic kidney disease, may play a major role in their high prevalence of endothelial dysfunction and subsequent cardiovascular disease. This study examined the association of advanced glycation end product accumulation with cellular receptor for advanced glycation end product expression and endothelial dysfunction as well as the mechanisms of this association in chronic kidney disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research