Neutrophil Gelatinase-Associated Lipocalin and Acute Kidney Injury after Cardiac Surgery | Zendy

David R. McIlroy | Zendy; Gebhard Wagener | Zendy; H. Thomas Lee | Zendy

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Neutrophil Gelatinase-Associated Lipocalin and Acute Kidney Injury after Cardiac Surgery

Author(s) -

David R. McIlroy,

Gebhard Wagener,

H. Thomas Lee

Publication year - 2010

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.04240609

Subject(s) - medicine , acute kidney injury , lipocalin , renal function , urinary system , creatinine , biomarker , urology , prospective cohort study , cardiac surgery , cardiology , biochemistry , chemistry

Neutrophil gelatinase-associated lipocalin (NGAL) is rapidly released by renal tubules after injury, potentially allowing early identification of acute kidney injury (AKI) after cardiac surgery. However, the diagnostic performance of NGAL has varied widely in clinical studies, and it remains unknown what factors modify the relationship between NGAL and AKI. We hypothesized the relationship between urinary NGAL and AKI would vary with baseline renal function, allowing a stratified analysis to improve diagnostic performance of this novel biomarker.

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