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Uromodulin and Nephron Mass
Author(s) -
Edward Pivin,
Belén Ponte,
Sophie de Seigneux,
Daniel Ackermann,
Idris Guessous,
Georg Ehret,
Antoinette Péchère-Bertschi,
Eric Olinger,
Markus G. Mohaupt,
Bruno Vogt,
PierreYves Martin,
Michel Burnier,
Murielle Bochud,
Olivier Devuyst,
Menno Pruijm
Publication year - 2018
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.03600318
Subject(s) - tamm–horsfall protein , nephron , medicine , renal function , urology , population , urinary system , kidney disease , kidney , environmental health
Every human is born with a certain number of nephrons. Assessing that number ( i.e. , nephron mass) is important because a low nephron mass at birth is a risk factor for hypertension and/or CKD. A reduced number of nephrons leads to hyperfiltration in the remaining ones, increasing intraglomerular

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