Incidence, Severity, and Outcomes of AKI Associated with Dual Renin-Angiotensin System Blockade | Zendy

Paul M. Palevsky | Zendy; Jane H. Zhang | Zendy; Stephen L. Seliger | Zendy; Nicholas Emanuele | Zendy; Linda F. Fried | Zendy

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Incidence, Severity, and Outcomes of AKI Associated with Dual Renin-Angiotensin System Blockade

Author(s) -

Paul M. Palevsky,

Jane H. Zhang,

Stephen L. Seliger,

Nicholas Emanuele,

Linda F. Fried

Publication year - 2016

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.03470316

Subject(s) - medicine , losartan , hazard ratio , renal function , creatinine , confidence interval , acute kidney injury , lisinopril , urology , kidney disease , clinical endpoint , angiotensin ii , randomized controlled trial , angiotensin converting enzyme , blood pressure

The benefit of dual blockade of the renin-angiotensin system is limited by adverse effects. We performed a secondary analysis of the Veterans Affairs Nephropathy in Diabetes (VA NEPHRON-D) Study to describe the effect of increased intensity of renin-angiotensin system blockade on the incidence, risk factors, and outcomes of AKI.

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