Open AccessEffect of Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) and the Proinflammatory RAGE Ligand (EN-RAGE, S100A12) on Mortality in Hemodialysis Patients
Author(s) -
Ayumu Nakashima,
Juan Jesús Carrero,
Abdul Rashid Qureshi,
Tetsu Miyamoto,
Björn Anderstam,
Peter Bárány,
Olof Heimbürger,
Peter Stenvinkel,
Bengt Lindholm
Publication year - 2010
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.03360410
Subject(s) - medicine , proinflammatory cytokine , glycation , hemodialysis , rage (emotion) , hazard ratio , inflammation , dialysis , prospective cohort study , c reactive protein , gastroenterology , endocrinology , confidence interval , receptor , neuroscience , biology
The soluble receptor of advanced glycation end products (sRAGE) may exert anti-inflammatory protective roles on the vasculature. In contrast, the RAGE ligand S100A12 (also known as EN-RAGE) contributes to inflammation and the development of atherosclerosis in animal models. Whether alterations at this level contribute to the increased mortality observed in patients on dialysis is currently unknown.