Decreased Conversion of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 Following Cholecalciferol Therapy in Patients with CKD | Zendy

Jason R. Stubbs | Zendy; Shiqin Zhang | Zendy; Peter A. Friedman | Zendy; Thomas D. Nolin | Zendy

Open Access

Decreased Conversion of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 Following Cholecalciferol Therapy in Patients with CKD

Author(s) -

Jason R. Stubbs,

Shiqin Zhang,

Peter A. Friedman,

Thomas D. Nolin

Publication year - 2014

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.03130314

Subject(s) - medicine , cholecalciferol , vitamin d and neurology , interquartile range , endocrinology , vitamin d deficiency , calcifediol , vitamin , fibroblast growth factor 23 , renal function , prospective cohort study , metabolite , gastroenterology , parathyroid hormone , calcium

Elevated concentrations of fibroblast growth factor 23 (FGF23) are postulated to promote 25-hydroxyvitamin D (25[OH]D) insufficiency in CKD by stimulating 24-hydroxylation of this metabolite, leading to its subsequent degradation; however, prospective human studies testing this relationship are lacking.

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