Open AccessRelationship between Epoetin Alfa Dose and Mortality
Author(s) -
Ouhong Wang,
Ryan D. Kilpatrick,
Cathy W. Critchlow,
Xiang Liu,
Brian D. Bradbury,
David T. Gilbertson,
Allan J. Collins,
Kenneth J. Rothman,
John F. Acquavella
Publication year - 2010
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.03040509
Subject(s) - medicine , marginal structural model , hazard ratio , confidence interval , epoetin alfa , confounding , proportional hazards model , observational study , dosing , truncation (statistics) , anemia , statistics , mathematics
Observational studies relating epoetin alfa (EPO) dose and mortality frequently use analytic methods that do not control time-dependent confounding by indication (CBI). The relationship between EPO dose and 1-year mortality, adjusting for the effects of time-dependent CBI, was examined using a marginal structural model.