Open AccessValidation Study of Oxford Classification of IgA Nephropathy
Author(s) -
Ritsuko Katafuchi,
Toshiharu Ninomiya,
Masaaki Nagata,
Koji Matsumoto,
Hideki Hirakata
Publication year - 2011
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.02890311
Subject(s) - medicine , univariate analysis , nephropathy , clinical significance , creatinine , cohort , gastroenterology , urology , multivariate analysis , pathology , endocrinology , diabetes mellitus
BACKGROUND AND OBJECTIVES The Oxford classification of IgA nephropathy (IgAN) includes mesangial hypercellularity, endocapillary hypercellularity, segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as prognosticators. The value of extracapillary proliferation (Ex) was not addressed. Because the Oxford classification excludes patients with urinary protein <0.5 g/d and eGFR <30 ml/min per 1.73 m(2) at biopsy, the significance of Ex should be confirmed by validation cohorts that include more rapidly progressive cases. We present such a study.