Alternative Pathway of Complement in Children with Diarrhea-Associated Hemolytic Uremic Syndrome | Zendy

Joshua M. Thurman | Zendy; Russell Marians | Zendy; Woodruff Emlen | Zendy; Susan Wood | Zendy; Christopher Smith | Zendy; Hillary Akana | Zendy; V. Michael Holers | Zendy; Martin Lesser | Zendy; Myriam Kline | Zendy; Cathy Hoffman | Zendy; Erica Christen | Zendy; Howard Trachtman | Zendy

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Alternative Pathway of Complement in Children with Diarrhea-Associated Hemolytic Uremic Syndrome

Author(s) -

Joshua M. Thurman,

Russell Marians,

Woodruff Emlen,

Susan Wood,

Christopher Smith,

Hillary Akana,

V. Michael Holers,

Martin Lesser,

Myriam Kline,

Cathy Hoffman,

Erica Christen,

Howard Trachtman

Publication year - 2009

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.02730409

Subject(s) - medicine , atypical hemolytic uremic syndrome , diarrhea , alternative complement pathway , complement system , complement (music) , immunology , gastroenterology , antibody , biochemistry , chemistry , complementation , gene , phenotype

Diarrhea-associated hemolytic uremic syndrome (D+HUS) is a common cause of acute kidney injury in children. Mutations in alternative pathway (AP) complement regulatory proteins have been identified in severe cases of thrombotic microangiopathy, but the role of the AP in D+HUS has not been studied. Therefore, we determined whether plasma levels of markers of activation of the AP are increased in D+HUS and are biomarkers of the severity of renal injury that predict the need for dialysis.

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