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Novel Treatments of Autosomal Dominant Polycystic Kidney Disease
Author(s) -
Rex L. Mahnensmith
Publication year - 2014
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.02480314
Subject(s) - pkd1 , nephron , autosomal dominant polycystic kidney disease , medicine , polycystic kidney disease , kidney , cyst , arginine vasopressin receptor 2 , kidney disease , autosomal recessive polycystic kidney disease , vasopressin , pathology , endocrinology , cancer research , receptor , antagonist
Autosomal dominant polycystic kidney disease (ADPKD) is considered the most common inherited form of kidney disease across all ethnic types ([1][1]–[3][2]). Present understanding holds that mutations of responsible genes, either PKD1 or PKD2, occur during embryogenesis and variably combine with

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