HMG–CoA Reductase Activation and Urinary Pellet Cholesterol Elevations in Acute Kidney Injury | Zendy

Ali C.M. Johnson | Zendy; Lorraine B. Ware | Zendy; Jonathan Himmelfarb | Zendy; Richard A. Zager | Zendy

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HMG–CoA Reductase Activation and Urinary Pellet Cholesterol Elevations in Acute Kidney Injury

Author(s) -

Ali C.M. Johnson,

Lorraine B. Ware,

Jonathan Himmelfarb,

Richard A. Zager

Publication year - 2011

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.02440311

Subject(s) - medicine , acute kidney injury , kidney disease , cholesterol , urinary system , endocrinology , kidney , creatinine , urine , biomarker , biology , biochemistry

Experimental acute kidney injury (AKI) activates the HMG-CoA reductase (HMGCR) gene, producing proximal tubule cholesterol loading. AKI also causes sloughing of proximal tubular cell debris into tubular lumina. This study tested whether these two processes culminate in increased urinary pellet cholesterol content, and whether the latter has potential AKI biomarker utility.

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