Association between Serum β2-Microglobulin Level and Infectious Mortality in Hemodialysis Patients | Zendy

Alfred K. Cheung | Zendy; Tom Greene | Zendy; John K. Leypoldt | Zendy; Guofen Yan | Zendy; Michael Allon | Zendy; James A. Delmez | Zendy; Andrew S. Levey | Zendy; Nathan W. Levin | Zendy; Michael V. Rocco | Zendy; Gerald Schulman | Zendy; Garabed Eknoyan | Zendy

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Association between Serum β2-Microglobulin Level and Infectious Mortality in Hemodialysis Patients

Author(s) -

Alfred K. Cheung,

Tom Greene,

John K. Leypoldt,

Guofen Yan,

Michael Allon,

James A. Delmez,

Andrew S. Levey,

Nathan W. Levin,

Michael V. Rocco,

Gerald Schulman,

Garabed Eknoyan

Publication year - 2007

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.02340607

Subject(s) - medicine , hazard ratio , hemodialysis , beta 2 microglobulin , dialysis , confidence interval , proportional hazards model , cohort , cohort study

Secondary analysis of the Hemodialysis Study showed that serum beta(2)-microglobulin levels predicted all-cause mortality and that high-flux dialysis was associated with decreased cardiac deaths in hemodialysis patients. This study examined the association of serum beta(2)-microglobulin levels and dialyzer beta(2)-microglobulin kinetics with the two most common causes of deaths: Cardiac and infectious diseases. Cox regression analyses were performed to relate cardiac or infectious deaths to cumulative mean follow-up predialysis serum beta(2)-microglobulin levels while controlling for baseline demographics, comorbidity, residual kidney function, and dialysis-related variables.

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