Open AccessCoronary Flow Velocity Reserve and Carotid Intima Media Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease
Author(s) -
Kültiğin Türkmen,
Hüseyin Oflaz,
Bora Uslu,
Arif Oğuzhan Çımen,
Ali Elıtok,
Erdem Kaşıkçıoğlu,
Sabahat Alışır,
Fatih Tufan,
Şule Namli,
Mükremın Uysal,
Tevfik Ecder
Publication year - 2008
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.02330607
Subject(s) - medicine , autosomal dominant polycystic kidney disease , cardiology , intima media thickness , disease , carotid arteries
Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease. Endothelial dysfunction, an early and reversible feature in the pathogenesis of atherosclerosis, is associated with increased vascular smooth muscle tone, arterial stiffening, and increased intima-media thickness. Coronary flow velocity reserve is a noninvasive test showing endothelial function of epicardial coronary arteries and coronary microcirculatory function. The aim of the study was to investigate the carotid intima-media thickness and coronary flow velocity reserve in patients with autosomal dominant polycystic kidney disease.