Impact of Gestational Age and Birth Weight on Amikacin Clearance on Day 1 of Life
Author(s) -
Michiel F. Schreuder,
Abraham J. Wilhelm,
Arend Bökenkamp,
Simone M.H. Timmermans,
Henriëtte A. Delemarrevan de Waal,
J. A. E. van Wijk
Publication year - 2009
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.02230409
Subject(s) - medicine , amikacin , gestational age , birth weight , population , renal function , pediatrics , low birth weight , obstetrics , pregnancy , antibiotics , environmental health , biology , microbiology and biotechnology , genetics
Intrauterine growth restriction (IUGR) and prematurity are associated with a low nephron endowment. It can therefore be expected that neonates who are born premature and/or after IUGR have a lower GFR. Measurement of GFR in neonates is difficult, but the clearance of amikacin has been proven to be a reliable marker. We hypothesized that amikacin clearance is lower after IUGR or premature birth as a marker of low nephron endowment.
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